Liquid chromatography on chip

Continuous sampling and analysis by on-chip liquid/solid chromatography

This paper describes a lab-on-a-chip device for continuous liquid/solid chromatography measurements. Chromatographic separations of phenolic test solutions as well as of vitamins are illustrating the ability and versatility of the system. The ependence of the peak height and width with respect to the injected plug and the saturation limits of the microchip column have been investigated nd good ...

High-Pressure Open-Channel On-Chip Electroosmotic Pump for Nanoflow High Performance Liquid Chromatography

Here, we construct an open-channel on-chip electroosmotic pump capable of generating pressures up to ∼170 bar and flow rates up to ∼500 nL/min, adequate for high performance liquid chromatographic (HPLC) separations. A great feature of this pump is that a number of its basic pump units can be connected in series to enhance its pumping power; the output pressure is directly proportional to the n...

Virus Detection by On-chip Hydroxyapatite Chromatography

We have succeeded in isolating virus from the particle laden solution like body fluid. Because many of virus infectious diseases occur in the developing region, compact and low-cost device for virus detection from the patients’ body fluid is required. We proposed a microfluidic chip for virus isolation by hydroxyapatite chromatography. This microfluidic chip utilized a column and a pair of swit...

Ion Exclusion Chromatography: Liquid Chromatography

terials, operated in a pressure-driven mode, plotted as a function of inverse temperature. This Rgure is intended to give some appreciation of the Suxes that are attainable; however, they are not normalized to a given partial pressure gradient or thickness of membrane, and thus the Suxes are not directly comparable. Taking a value of between 10 and 100 L m 2 min 1 as the level of oxygen Sux nee...

Liquid chromatography.